Commonly used Imaging modalities/biomarkers in neuroscience are MRI & PET.

  • Primary endpoints

  • Secondary endpoints, or selected group review

  • Proof of Concept or Proof of Principle situations

This PoC/PoP category is getting a lot of attention, as for some investigational drugs the exact response of tissue and disease is not fully researched.
This PoC/PoP category is getting a lot of attention, as for some investigational drugs the exact response of tissue and disease is not fully researched.   
Connected to the PoC / PoP category is also the use of investigational imaging techniques which require a lot of attention with regard to standardised production, QA, QC of data and central reading. Connected to the PoC / PoP category is also the use of investigational imaging techniques which require a lot of attention with regard to standardised production, QA, QC of data and central reading. NeuroScios offers a wide range of support with regard to this category.

Biomarker modalities

have several techniques that are tailored to the expected treatment response.

PET Examples for Alzheimer’s Disease:

  • FDG PET                      

  • PIB PET or other PET Amyloid biomarkers      

  

In biomarker MRI for Alzheimer’s Disease,

the most favourite sequence is the 3DT1 sequence. With a properly acquired 3DT1 sequence a wide selection of brain volume data can be generated. It’s however extremely important that the 3DT1 sequence is exactly done as required, the challenge is that the requirements vary per MRI scanner vendor & type.

Phantom Imaging plays an important role in the Quality Assurance of Biomarker MRI sequences.                  

Data based on the 3DT1 sequence*: Whole Brain Volume (WBV), Ventricular Volume (VV), Hippocampal Volume (HV) and Amygdala Volume (AV), Entorhinal Cortex volume (ERC)